Begin treatment withĬorticosteroids once engraftment syndrome is recognized in order to Syndrome may progress to multiorgan failure and death. Unexplained weight gain, hypoxemia, and pulmonary infiltrates in theĪbsence of fluid overload or cardiac disease. Patients with engraftment syndrome also may have Engraftment SyndromeĮngraftment syndrome is manifested as unexplained fever and rash in the Transplanted with HEMACORD® (HPC, Cord Blood) also should receive immunosuppressive drugs toĭecrease the risk of GVHD. Rash, elevated bilirubin and liver enzymes, and diarrhea. Who have received HEMACORD® (HPC, Cord Blood) Classic acute GVHD is manifested as fever, Graft-versus-Host DiseaseĪcute and chronic graft-versus-host disease (GVHD) may occur in patients When a reaction occurs, discontinue the infusion and Monitor the patient closelyĭuring this period. Several hours after completion of the infusion. HEMACORD® (HPC, Cord Blood), although symptoms may continue to intensify and not peak for Infusion reactions may begin within minutes of the start of infusion of Signs and symptoms of infusion reactions from the prior unit have If infusing more than one unit of HPC,Ĭord Blood on the same day, do not administer subsequent units until all Limiting the amount of DMSO infused to no more The actual amount of DMSO depends on the method of preparation The amount of DMSO administered may reduce the risk of such reactions,Īlthough idiosyncratic responses may occur even at DMSO doses thought to be These reactions are related to the amount of DMSO administered. Hypotension, hemolysis, elevated liver enzymes, renal compromise,Įncephalopathy, loss of consciousness, and seizure also may occur. Severe bradycardia with heart block or other arrhythmias, cardiac arrest, Severe reactions, including respiratory distress, severe bronchospasm, Premedication with antipyretic, histamine antagonists, andĬorticosteroids may reduce the incidence and intensity of infusion Hypertension, tachycardia, bradycardia, dysgeusia, hematuria, and mild Infusion reactions are expected to occur and include nausea, vomiting,įever, rigors or chills, flushing, dyspnea, hypoxemia, chest tightness, Patients with a history of allergic reactions to antibiotics should be monitored for allergic reactions following HEMACORD (HPC, Cord Blood) administration. ![]() HEMACORD (HPC, Cord Blood) may contain residual antibiotics if the cord blood donor was exposed to antibiotics in utero. These reactions may be due to dimethyl sulfoxide (DMSO), Dextran 40, or a plasma component of HEMACORD (HPC, Cord Blood). Serious hypersensitivity reactions, including anaphylaxis, also have been reported. Reactions include bronchospasm, wheezing,angioedema, pruritus and hives. Important Safety Information Warnings and Precautions Hypersensitivity ReactionsĪllergic reactions may occur with infusion of HPC, Cord Blood, including HEMACORD (HPC, Cord Blood).
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